Fa·tigue, v. t. [imp. & p. p. Fatigued p. pr. & vb. n. Fatiguing, n.] To weary with labor or any bodily or mental exertion; to harass with toil; to exhaust the strength or endurance of; to tire. Syn: -- To jade; tire; weary; bore. See Jade. ◄ ►