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From: Webster's Revised Unabridged Dictionary (1913)

 Ca·lum·ba n.  Med. The root of a plant (Jateorrhiza Calumba, and probably Cocculus palmatus), indigenous in Mozambique. It has an unpleasantly bitter taste, and is used as a tonic and antiseptic. [Written also colombo, columbo, and calombo.]
 American calumba, the Frasera Carolinensis, also called American gentian. Its root has been used in medicine as bitter tonic in place of calumba.