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From: Webster's Revised Unabridged Dictionary (1913)

 Me·di·as·tine Me·di·as·ti·num n.  Anat. A partition; a septum; specifically, the folds of the pleura (and the space included between them) which divide the thorax into a right and left cavity. The space included between these folds of the pleura, called the mediastinal space, contains the heart and gives passage to the esophagus and great blood vessels.