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From: Webster's Revised Unabridged Dictionary (1913)

 Plague n.
 1. That which smites, wounds, or troubles; a blow; a calamity; any afflictive evil or torment; a great trail or vexation.
    And men blasphemed God for the plague of hail.   --Wyclif.
    The different plague of each calamity.   --Shak.
 2. Med. An acute malignant contagious fever, that often prevails in Egypt, Syria, and Turkey, and has at times visited the large cities of Europe with frightful mortality; hence, any pestilence; as, the great London plague. “A plague upon the people fell.”
 Cattle plague. See Rinderpest.
 Plague mark, Plague spot, a spot or mark of the plague; hence, a token of something incurable.