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2 definitions found

From: Webster's Revised Unabridged Dictionary (1913)

 knockout drops, knock-out drops n. pl. Drops of any drug, used to a person to fall asleep or become unconscious or stupefied for the purpose of robbery, etc.; they are usually mixed into a drink so that the person consuming it does so unknowingly.  One compound used for this purpose is chloral hydrate. [Slang, U. S.]
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From: WordNet (r) 2.0

 knockout drops
      n : chloral hydrate in combination with alcohol; usually
          administered surreptitiously to make the drinker
          unconscious [syn: Mickey Finn]