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From: MDBG CC-CEDICT Chinese-English Dictionary 漢英字典

 一蹶不振 [ㄧ ㄐㄩㄝˊ ㄅㄨˋ ㄓㄣˋ; yi1 jue2 bu4 zhen4]
 one stumble, unable to rise (idiom); a setback leading to total collapse
 ruined at a stroke
 unable to recover after a minor hitch